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Curing Cancer With Viruses

HandelontheLaw.com Staff Writer

Tuesday, March 31, 2015



Curing Cancer With Viruses
Virus

In late March 2015, media focused on the work of Dr. Matthias Gromeier and others at Duke University’s Preston Robert Tisch Brain Tumor Center in fighting brain tumors with genetically altered poliovirus.

A brief, and therefore inadequate, explanation of the treatment is:
1. doctors remove part of the poliovirus’ genetic material and replace it with a human rhinovirus (the type causing the common cold) so the poliovirus cannot harm normal cells;
2. a small amount of the altered poliovirus is infused into a brain tumor once via a 1-millimeter diameter catheter inserted through the skull and directed by 3-D imaging;
3. the altered poliovirus removes the protective measures that all human cancers supposedly have to shield them from our immune system;
4. the cancer cells burst open and are killed without affecting normal cells; the tumor shrinks, ideally to nothing.

The treatment is dedicated to fighting an especially deadly type of brain tumor called glioblastoma multiforme (GBM) and is currently in human safety trial (a Phase I study). The Phase I study aims to develop the correct dosage of altered poliovirus, strong enough to effectively combat the cancer yet not so strong that it prompts dangerous immune responses like massive swelling of the brain. To date, 22 patients received the treatment, 11 died, 11 have improved and 3 of the fortunate 11 are cancer-free. The researchers are welcoming participants who can contact them here: http://www.cancer.duke.edu/btc/modules/Research3/index.php?id=41 or by calling 919-684-5301.

Amazing, isn’t it? Yet, researchers have been working with cancer-fighting viruses for decades because some types of viruses can apparently enter any bodily cell and kill it. That’s quite valuable when dealing with human cancers, all of which reportedly develop shields from our immune systems.

Dr. Gromeier himself has worked with the poliovirus for 25 years, first at State University of New York at Stony Brook and obtaining patents for the therapy with virologist and organic chemist Eckard Wimmer and the Research Foundation of SUNY at Stony Brook in 2003 and 2006.

The HIV virus is also being tested for cancer treatment. Pennsylvania University researchers are working on a cancer treatment in which white blood cells are removed from a cancer patient’s body, re-engineered by genetically altered HIV virus and re-infused into the patient’s body to attack the cancer. That treatment, financially supported by a company called Novartis, is supposedly close to application for FDA approval.

The Herpes Simplex virus is also being tested for cancer treatment, specifically to fight melanoma. The treatment, called T-Vec and owned by Amgen, is set for review by 2 of the FDA’s independent expert committees on April 29th and the FDA says it will issue a final decision on T-Vec’s approval by October 27th.

These are just a few of the dozens of experimental treatments using genetically altered viruses. How ironic that the poliovirus, HIV, Herpes Simplex and other viruses normally associated with paralysis, autoimmune disease, infections and other human scourges will kill one of our most feared killers: Cancer.


By Kathy Catanzarite


Source: Kathy Catanzarite - Handelonthelaw.com Staff Writer

Note from HandelontheLaw.com: This article is to be used as an educational guide only and should not be interpreted as a legal consultation. Readers of this article are advised to seek an attorney if a legal consultation is needed. Laws may vary by state and are subject to change, thus the accuracy of this information can not be guaranteed. Readers act on this information solely at their own risk. Neither the author, handelonthelaw.com, or any of its affiliates shall have any liability stemming from this article.





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